[* denotes corresponding author; UG students are underlined]
Independent Research:
21. Kanabar, D.; Kabir, A.; Chavan, T.; Kong, J.; Yoganathan, S.; Muth, A. Identification of novel gankyrin binding scaffolds by high throughput virtual screening. Bioorg. Med. Chem. Lett. 2021, in press
20. Yoganathan, S.*; Alagaratnam, A.; Acharekar, N.; Kong, J. Ellagic Acid and Schisandrins: Natural Biaryl Polyphenols with Therapeutic Potential to Overcome Multidrug Resistance in Cancer. Cells, 2021, 10, 458.
19. Kong, J.; Wu, X. -Z.; Wei, L.; Chen, Z. -S.*; Yoganathan, S.* Exploration of antibiotic activity of aminoglycosides, in particular ribostamycin alone and in combination with EDTA against pathogenic bacteria. Front. Microbiol., 2020, 11, 1718.
18. Barasa, L.; Yong, A.; Yoganathan, S.* An efficient chemo-selective N-alkylation methodology for the structure diversification of indolylbenzimidazoles. ChemistrySelect, 2020, 5, 3173-3178.
17. Gupta, P.; Zhang, G. -N.; Barbuti, A. M.; Zhang, X.; Karadkhelkar, N.; Zhou, J.; Ding, K.; Pan, J.; Yoganathan, S.; Yang, D. -H.; Chen, Z. -S. Preclinical development of a novel BCR-ABL-T315I inhibitor against chronic myeloid leukemia. Cancer Lett. 2020, 472, 132-141.
16. Barasa, L.; Vemana, H.; Surubhotla, N.; Ha, S. S.; Kong, J.; Yong, A.; Croft, J. L.; Dukhande, V.*; Yoganathan, S.* Synthesis and biological evaluation of structurally diverse benzimidazole scaffolds as potential anticancer agents. Anti-Cancer Agents Med. Chem. 2020, 20, 301-314.
15. Shao, X.; AbdelKhalek, A.; Abutaleb, N. S.; Velagapudi, U. K.; Yoganathan, S.; Seleem, M. N.; Talele, T. T. Chemical space exploration around thieno[3,2-d]pyrimidin-4(3H)-one scaffold led to a novel class of highly active Clostridium difficile inhibitors. J. Med. Chem. 2019, 62, 9772-9791.
14. Gandhi, T.; Patki, M.; Kong, J.; Koya, J.; Yoganathan, S.; Reznik S.; Patel, K. Development of arginine anchored nano-globule with retrograde trafficking inhibitor (Retro-2) for the treatment of Enterohemorrhagic Escherichia coli outbreak. Mol. Pharmaceutics, 2019, 16, 4405-4415.
13. Kulkarni, N. S.; Parvathaneni, V.; Shukla, S. K.; Barasa, L.; Perron, J. C.; Yoganathan, S.; Muth, A.; Gupta, V. Tyrosine kinase inhibitor conjugated quantum dots for non-small cell lung cancer (NSCLC) treatment. Eur. J. Pharm. Sci. 2019, 15, 145-159.
12. Gupta, P.; Gao, H. -L.; Ashar, Y. V.; Karadkhelkar, N.; Yoganathan, S.; Chen, Z. -S. Ciprofloxacin enhances the chemosensitivity of cancer cells to ABCB1 substrates. Int. J. Mol. Sci. 2019, 20, 268-279.
11. Barasa, L.; Yoganathan, S.* An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology. RSC Adv. 2018, 8, 35824-35830.
10. Gorasiya, S.; Pekson, R.; Yoganathan, S.; Reznik, S. E.* Repurposing N,N-dimethylacetamide (DMA), a pharmaceutical excipient as a prototype novel anti-inflammatory agent for the prevention and/or treatment of preterm-birth. Curr. Pharm. Des. 2018, 24, 989-992.
9. Yang, C.; Schanne, A. X. F.; Yoganathan, S.*; Stephani, R. A.* Synthesis of N-1', N-3'-disubstituted spirohydantoins and their anticonvulsant activities in pilocarpine model of temporal lobe epilepsy. Bioorg. Med. Chem. Lett. 2016, 26, 2912–2914.
8. Yoganathan, S.; Miller, S. J.* Structure diversification of vancomycin through peptide-catalyzed, site-selective lipidation: A catalysis-based approach to combat glycopeptide-resistant pathogens. J. Med. Chem. 2015, 58, 2367–2377.
7. Yoganathan, S.; Yin, N.; He, Y.; Mesleh, M. F.; Gu, Y. G.; Miller, S. J.* An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin. Org. Biomol. Chem. 2013, 11, 4680-4685. (Designated as a “Hot Article” by the Editors of Org. Biomol. Chem.)
6. Yoganathan, S.; Miller, S. J.* N-methylimidazole-catalyzed synthesis of carbamates from hydroxamic acids via the Lossen rearrangement. Org. Lett. 2013,15, 602-605.
5. Yoganathan, S.; Sit, C. S.; Vederas, J. C.* Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates. Org. Biomol. Chem. 2011, 9, 2133-2141. (Designated as a “Hot Article” by the Editors of Org. Biomol. Chem.)
4. Martin-Visscher, L. A.; Yoganathan, S.; Sit, C. S.; Lohans, C. T.; Vederas, J. C.* The activity of bacteriocins from Carnobacterium maltaromaticum UAL307 against Gram-negative bacteria in combination with EDTA treatment. FEMS Microbiol. Lett. 2011, 317, 152-159.
3. Sit, C. S.; Yoganathan, S.; Vederas, J. C.* Biosynthesis of aminovinyl-cysteine containing peptides and its application in the production of potential drug candidates. Acc. Chem. Res. 2011, 44, 261-268.
2. Yoganathan, S.; Vederas, J. C.* Fracturing Rings to Understand Lantibiotics. Chem. Biol. 2008, 15, 999-1001.
1. Guenther, K. J.; Yoganathan, S.; Garofalo, R.; Kawabata, T.; Strack, T.; Labiris, R.; Dolovich, M.; Chirakal, R.; Valliant, J. F.* Synthesis and in Vitro Evaluation of 18F and 19F-Labeled Insulin: A New Radiotracer for PET-based Molecular Imaging Studies. J. Med. Chem. 2006, 49, 1466-1474.
